Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, McKinley ET, Ramirez Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS. Succinate produced by intestinal microbes promotes specification of tuft cells to suppress ileal inflammation. Gastroenterology, 159(6):2101-2115, 2020.
Heiser CN,Lau KS. A quantitative framework for evaluating single-cell data structure preservation by dimensionality reduction techniques. Cell Reports, 31(5):107576, 2020.
Macedonia MC, Drewes JL, Markham NO, Simmons AJ, Roland JT, Vega PN, Scurrah CR, Coffey RJ, Shrubsole MJ, Sears CL, Lau KS. Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms. npj Biofilms Microbiomes, 6(1): 33, 2020.
Southard-Smith AN, Simmons AJ, Chen B, Jones AL, Ramirez Solano MA, Vega PN, Scurrah CR, Zhao Y, Brenan MJ, Xuan J, Shrubsole MJ, Porter EB, Chen X, Brenan CJH, Liu Q, Quigley LMN*, Lau KS*. Dual indexed library design enables compatibility of in-Drop single-cell RNA-sequencing with exAMP chemistry sequencing platforms. BMC Genomics, 21: 456, 2020. *Corresponding Authors
Islam M, Chen B, Spraggins JM, Kelly RT, Lau KS. Use of single cell -omic technologies to study the gastrointestinal tract and diseases, from single cell identities to patient features. Gastroenterology, 159(2):453-466, 2020.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G. Coregulator Sin3a promotes postnatal murine β-Cell fitness by regulating genes in Ca2+ homeostasis, cell survival, vesicle Biosynthesis, glucose metabolism, and stress response. Diabetes, 69(6):1219-1231, 2020.
Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA. An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease. Science Signaling, 13(643): eaay3258, 2020.
Chinowsky CR, Pinette JA, Meederink LM, Lau KS, Tyska MJ. Non-muscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli. Molecular Biology of the Cell, 31(25):2803-2815, 2020.
Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe’er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH; Human Tumor Atlas Network. The Human Tumor Atlas Network: charting tumor transitions across space and time at single-cell resolution. Cell, 181(2):236-249, 2020.
Vickman RE, Faget DV, Beachy P, Beebe D, Bhowmick NA, Cukierman E, Deng WM, Granneman JG, Hildesheim J, Kalluri R, Lau KS , Lengyel E, Lundeberg J, Moscat J, Nelson PS, Pietras K, Politi K, Puré E, Scherz-Shouval R, Sherman MH, Tuveson D, Weeraratna AT, White RM, Wong MH, Woodhouse EC, Zheng Y, Hayward SW, Stewart SA. Deconstructing tumor heterogeneity: the stromal perspective. Oncotarget, 11(40):3621-3632, 2020.