Spencer PN, Brown ME, Smith EP, Wang J, Kim W, Spiga L, Tasneem N, Simmons AJ, Kim T, Yang Y, Xu Y, Zheng L, Ro J, Kaur H, Kang SW, Helou MD, Lee MA, Arceneaux D, Mueller KD, Kuddar OS, Harned MH, Li J, Banerjee A, Markham NO, Wilson KT, Coburn LA, Goettel JA, Liu Q, Washington MK, Valdivia RH, Zhu W, Lau KS . Pathobiont-triggered induction of goblet cell response drives regional susceptibility to Inflammatory Bowel Disease. Journal of Clinical Investigation, 136(7):e201729, 2026.
Evans JR, Simmons AJ, Chen Z, Brown ME, Bechard ME, Malek MC, Heiser CN, Revetta F, Washington MK, Hale LP, Coffey RJ, Lau KS. Intact cell dissociation of formalin-fixed paraffin-embedded colon tissue enhances cell recovery and gene detection in single-cell RNA sequencing. Cellular and Molecular Gastroenterology and Hepatology, 20(12):101863, 2026.
Huang Z, Brown ME, Lau KS. Roles for specialized secretory epithelial cells in inflammatory bowel disease. Current Opinion in Gastroenterology, 42(4):247-254, 2026.
Brown ME, Gleizes AR, Yu Q, Adhikari UD, Nagarajan R, Rout P, Camp JG, Yilmaz OH, Tape CJ, Tyska MJ, Verzi MP, Lau KS*, Gracz AD*. Current practices and considerations for benchmarking human gastrointestinal organoids. Cellular and Molecular Gastroenterology and Hepatology, 20(10):101832, 2026. *Corresponding Authors
Hoi XP, Stangis MM, Glass SE, Kim JH, Kang SW, Brennen WN, Li Z, Grady WM, Yegnasubramanian S, Kuhn P, Lyssiotis CA, Sagara A, Shrubsole MJ, Kadara H, Yuan Y, Coffey RJ, Lau KS , De Marzo AM, Maitra A, Min J, Yu M, Chan KS; TBEL Consortium. Cellular senescence in precancer lesions and early-stage cancers. Cancer Cell, 44(1):6-11, 2026.
Rispal J, Garcia JR, Palikuqi B, Vegesna M, Vaka D, Kang SW, Trentesaux C, Du J, Realini NR, Spencer PN, Gardner JM, Hausmann A, Kattah MG, Lau KS, Boffelli D, Klein OD. Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility. Cell, 189(9):2714-2730, 2026.
Loberg MA, Xu GJ, Chen SC, Chen HC, Wahoski CC, Caroland KP, Tigue ML, Hartmann HA, Gallant JN, Phifer CJ, Ocampo AA, Wang DK, Fankhauser RG, Karunakaran KA, Wu CC, Tarabichi M, Shaddy SM, Netterville JL, Rohde SL, Solórzano CC, Bischoff LA, Baregamian N, Murphy BA, Choe JH, Wang JR, Huang EC, Sheng Q, Kagohara LT, Jaffee EM, Belcher RH, Lau KS , Ye F, Lee E, Weiss VL. An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations. JCI Insight, 11(1):e191990, 2026.
Chen Z, Song W, Li Q, Li C, Wen W, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Timofeeva MN, Thomas M, Schmit SL, Martin V, Devall M, Dampier C, Moratalla-Navarro F, Cai Q, Wang J, Shi J, Kweon SS, Tanikawa C, Jia WH, Shu X, Long J, Gao J, Kim J, Shin A, Matsuo K, Jee SH, Jung KJ, Wang N, Kim DH, Ping J, Yang G, Shin MH, Ren Z, Oh JH, Oze I, Ahn YO, Gao YT, Pan ZZ, Kamatani Y, Van Kaer L, Wu L, Li B, Matsuda K, Shu XO, Hsu L, Dunlop MG, Gruber SB, Houlston R, Tomlinson I, Li L, Lau KS , Moreno V, Casey G, Peters U, Zheng W, Guo X. Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility. Nature Communications, 17(1):1377, 2026.
Liu Q, Wang Y, Hsu CY, Wanjalla CN, Lau KS , Shyr Y. Microenvironment-aware spatial modeling for accurate inference of cell identity. Nucleic Acids Research, 54(1):gkaf1477, 2026.
Li Q, Song Q, Chen Z, Choi J, Moreno V, Ping J, Wen W, Li C, Shu X, Yan J, Shu XO, Cai Q, Long J, Huyghe JR, Pai R, Gruber SB, Yang Y, Casey G, Wang X, Toriola AT, Li L, Singh B, Lau KS , Zhou L, Zhang Z, Wu C, Peters U, Zheng W, Long Q, Yin Z, Guo X. Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention. The American Journal of Human Genetics, 113(1):41-56, 2026.
Srinivasan J, Moore CR, Calindi A, Helm BR, Yang Y, Moore JF, Selden HJ, Heiser CN, Liu Q, Lau KS , Ehrlich LIR. The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types. Nature Immunology, 27(2):265-280, 2026.
Hu R, Wang Y, Yagan M, Xu Y, Simmons AJ, Lau KS , Liu Q, Gu G. Deregulated translation of the transcription factor Myt3 predisposes islet β-cells to dysfunction under obesity-induced metabolic stress. Journal of Biological Chemistry, 302(3):111164, 2026.
Ankenbauer KE, Yang Y, Chung CY, Andrade LR, Novak SW, Jarvis B, Ali Hanel WH, Liu J, Sarkisian V, Dani N, Krystofiak E, Hu G, Ebrahim S, Kachar B, Gong Q, Wahl GM, Lau KS , Brown JW, Manor U, DelGiorno KE. Protocadherin 20 is a POU Class 2 homeobox 3 target gene required for proper tuft cell microvillus organization. Cellular and Molecular Gastroenterology and Hepatology, 20(6):101742, 2026.
Burman A, Brown ME, Yang Y, Momoh M, Adeniran F, Ramos C, Lau KS, Samuelson LC, Shub MD, Roland JT, Kaji I. Myosin VB is critical for progenitor cell identity and function in the intestine. Stem Cell Reports, 21(3):102820, 2026.
Hu R, Hamilton N, Wang Y, Tong X, Yagan M, Dadi PK, Harmelink C, Doss TD, Liu J, Xu Y, Simmons AJ, Lau KS, Stein R, Balamurugan AN, Kaverina I, Coate KC, Jacobson DA, Liu Q, Gu G. Diabetes-associated MYT1 and ST18 genes regulate human beta cell insulin secretion and survival via other diabetes risk genes. Diabetologia, 69(9):2554-2568, 2026.
Rudravaram G, Bao S, Remedios LW, Krishnan AR, Kim ME, Liu Y, Gao C, Zhang R, Jiang B, Liu Q, Lau KS, Roland JT, Washington MK, Coburn LA, Wilson KT, Huo Y, Landman BA. Quantifying the efficacy of deep learning-driven deformable registration in multiplexed-immunofluorescence imaging for nucleus subtype Classification. Journal of Machine Learning for Biomedical Imaging, 2026:186-199, 2026.
Zhang Y, Cao H, Yu D, Feng W, Cao S, Zhou Y, Lau KS, Li Z. TIPE3 in cancer: A multifaceted regulator of tumorigenesis, therapeutic resistance, and clinical outcomes. Technology in Cancer Research and Treatment, 25:15330338261461720, 2026.
Hamilton MS, Ellis ST, Cao Z, Tutanov OS, Simmons AJ, Aramandla R, Higginbotham JN, Ramirez M, Schnee KW, Bechard ME, Kaur H, Franklin JL, Mandal S, Lau KS, Liu Q, Goettel JA, Pozzi A, Coffey RJ. Supermeres containing the discoidin domain receptor 1 extracellular domain promote collagen alignment and immune exclusion in microsatellite-stable colorectal cancer. Cancer Research Communications, 6(9):2149-2163, 2026.
Bechard ME, Chen Z, Zhao P, Aramandla R, Yang Y, Simmons AJ, Washington MK, Franklin JL, Lau KS, Coffey RJ. Opposing effects of LRIG1 and LRIG3 on EGFR maintain intestinal homeostasis and mitigate likelihood of colonic neoplasia. Cellular and Molecular Gastroenterology and Hepatology, 20(12):101873, 2026.