2025

Brown ME, Lau KS. The Great Reset: A “Tuft” Journey Towards Tumorigenesis. Cellular and Molecular Gastroenterology and Hepatology, 19(6):101476, 2025.

Brown ME, Miranda VE, Nevills S, Hu R, Dadi PK, Simmons AJ, Xu Y, Yang Y, Yagan M, Najam S, Sampson LL, Magnuson MA, Jacobson DA, Lau KS* , Hodges E*, Gu G*. Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors. Nature Communications , 16(1):5758, 2025. *Corresponding Authors

Yagan M, Najam S, Hu R, Wang Y, Dickerson M, Dadi P, Xu Y, Simmons AJ, Stein R, Adams CM, Jacobson DA, Lau KS, Liu Q, Gu G. Atf4 protects islet β-cell identity and function under acute glucose-induced stress but promotes β-cell failure in the presence of free fatty acid. Diabetes, 74(5):838-849, 2025.

Li J, Jacobse J, Pilat JM, Kaur H, Gu W, Kang SW, Rusznak M, Huang HI, Barrera J, Oloo PA, Roland JT, Hawkins CV, Pahnke AP, Khalil M, Washington MK, Wilson KT, Williams CS, Peebles RS Jr, Konnikova L, Choksi YA, Hammer GE, Lau KS, Goettel JA. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal Immunology, 18(3):643-655, 2025.

Green EH, Kotrannavar SR, Rutherford ME, Lunnemann HM, Kaur H, Heiser CN, Ding H, Simmons AJ, Liu X, Lacy DB, Washington MK, Shrubsole MJ, Liu Q, Lau KS, Sears CL, Coffey RJ, Drewes JL, Markham NO. Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia. Journal of Pathology, 266(1):51-65, 2025.

Kang SW, Helm BR, Wang Y, Xiao S, Zhang W, Vasudev A, Lau KS, Liu Q, Richie ER, Hale LP, Manley NR. Insulin-like growth factor 2 as a driving force of exponential expansion and differentiation of neonatal thymus. Development, 152(7):dev204347, 2025.

Glass SE, Bechard ME, Cao Z, Aramandla R, Zhao P, Ellis ST, Green EH, Fisher EG, Smith RT, Sievers CK, Irudayam MJ, Revetta F, Washington MK, Ayers GD, Heiser CN, Simmons AJ, Xu Y, Wang Y, Windon A, Shrubsole MJ, Markham NO, Liu Q, Lau KS, Coffey RJ. Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer. JCI Insight, 10(9):e186938, 2025.

Hamann CA, Kjar A, Kim H, Simmons AJ, Brien HJ, Quartey CI, Walton BL, Lau KS, Lippmann ES, Brunger JM. Induced Neural Progenitor Specification from Human Pluripotent Stem Cells by a Refined Synthetic Notch Platform. American Chemical Society Synthetic Biology, 14(5):1482–1495, 2025.

Guerin LN, Scott TJ, Yap JA, Johansson A, Puddu F, Charlesworth T, Yang Y, Simmons AJ, Lau KS, Ihrie RA, Hodges E. Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification. Cell Reports, 44(5):115680, 2025.

Zhang R, Chiron S, Tyree R, Carson K, Raber L, Ramadass K, Gao C, Kim ME, Zuo L, Li Y, Wan Z, Harris PA, Liu Q, Lau KS , Coburn LA, Wilson KT, Huo Y, Landman BA, Bao S. Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study. Journal of Medical Internet Research Formative Research , 9:e70016, 2025.

Harmych SJ, Hasaka TP, Sievers CK, Kang SW, Ramirez MA, Jones VT, Zhao Z, Kovtun O, Wahoski CC, Liu Q, Lau KS , Coffey RJ, Bauer JA, Singh B. 3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer. Communications Biology , 8(1):1261, 2025.

Srinivasan G, Le MK, Azher Z, Liu X, Vaickus L, Kaur H, Kolling F 4th, Palisoul S, Perreard L, Lau KS , Yao K, Levy J. Histology-Based Virtual RNA Inference Identifies Pathways Associated with Metastasis Risk in Colorectal Cancer. Modern Pathology , 38(11):100866, 2025.

Alonso S, Kaur H, Jia L, Nguyen MU, Laguerta A, Fong A, Skariah N, Argüello RJ, Verzi MP, Swamy M, Lau KS , Edelblum KL. Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling. Mucosal Immunology , 18(5):1184-1198, 2025.

Shui L, Maitra A, Yuan Y, Lau K , Kaur H, Li L, Li Z. Translational and Basic Science Research in Early Lesions Research Consortia. PoweREST: Statistical power estimation for spatial transcriptomics experiments to detect differentially expressed genes between two conditions. PLoS Computational Biology , 21(7):e1013293, 2025.

Zhang R, Chiron S, Tyree R, Carson K, Raber L, Ramadass K, Gao C, Kim ME, Zuo L, Li Y, Wan Z, Harris PA, Liu Q, Lau KS , Coburn LA, Wilson KT, Huo Y, Landman BA, Bao S. Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study. Journal of Medical Internet Research Formative Research, 9:e70016, 2025.

Srivastava A, Shaik N, Lu Y, Chan M, Diallo A, Zavras J, Han S, Punshon T, Jackson B, Vahdat L, Liu X, Mittal V, Lau K , Gui J, Vaickus L, Hoopes J, Kolling F, Perreard L, Marotti J, Levy J. Integration of Elemental Imaging and Spatial Transcriptomic Profiling for Proof-of-Concept Metals-Based Pathway Analysis of Colon Tumor Microenvironment. Metallomics, 17(10):mfaf034, 2025.

Rudravaram G, Bao S, Krishnan AR, Remedios LW, Kim ME, Saunders AM, Liu Q, Lau KS , Roland JT, Washington MK, Coburn LA, Wilson KT, Huo Y, Landman BA. Identifying Cellular Neighborhood Phenotypes Differentiating Normal and Quiescent Crohn’s Disease via MxIF. Proceedings of Society of Photo-Optical Instrumentation Engineers, 13413:134130Q, 2025.

Bao S, Wang Y, Rudravaram G, Zhang R, Deng R, Yu X, Gao C, Li J, Li Y, Roland JT, Zuo L, Liu Q, Lau KS , Coburn LA, Wilson KT, Landman BA, Huo Y. Quantitative Analysis of Colonic Epithelial Cell Aging in a Cell-cycle like Model: Changes in Nucleus and Cytoplasm Along the Crypt Axis. Proceedings of Society of Photo-Optical Instrumentation Engineers, 13413:134130U, 2025.

Quoc-Huy Trinh V, Ankenbauer KE, Torbit SM, Taranto CP, Liu J, Batardiere M, Kumar B, Maurer HC, Revetta F, Chen Z, Kruse ARS, Judd AM, Copeland C, Wong J, Ben-Levy O, Jarvis B, Brown M, Brown JW, Das K, Makino Y, Spraggins JM, Lau KS , Azadi P, Maitra A, Tan MCB, DelGiorno KE. Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia. Cell Reports, 44(12):116684, 2025.

Vasudev A, Moore CR, Calindi A, Kang SW, Helm BR, Srinivasan J, Shah S, Baker E, Zong R, Singarapu N, Casey S, Macintyre AN, Lau KS , Hale LP, Liu Q, Manley NR, Ehrlich LIR, Richie ER. Coordinated changes in stromal and hematopoietic cells that define the perinatal to juvenile transition in the mouse thymus. Cell Reports, 44(12):116677, 2025.